| Title | In Vitro Validation of a Numerical Simulation of Leaflet Kinematics in a Polymeric Aortic Valve Under Physiological Conditions. |
| Publication Type | Journal Article |
| Year of Publication | 2018 |
| Authors | Gharaie SHassanzade, Mosadegh B, Morsi Y |
| Journal | Cardiovasc Eng Technol |
| Volume | 9 |
| Issue | 1 |
| Pagination | 42-52 |
| Date Published | 2018 03 |
| ISSN | 1869-4098 |
| Keywords | Aortic Valve, Biomechanical Phenomena, Computer Simulation, Heart Valve Prosthesis, Heart Valve Prosthesis Implantation, Hemodynamics, Humans, Materials Testing, Models, Cardiovascular, Numerical Analysis, Computer-Assisted, Polymers, Prosthesis Design, Reproducibility of Results |
| Abstract | This paper describes a computational method to simulate the non-linear structural deformation of a polymeric aortic valve under physiological conditions. Arbitrary Lagrangian-Eulerian method is incorporated in the fluid-structure interaction simulation, and then validated by comparing the predicted kinematics of the valve's leaflets to in vitro measurements on a custom-made polymeric aortic valve. The predicted kinematics of the valve's leaflets was in good agreement with the experimental results with a maximum error of 15% in a single cardiac cycle. The fluid-structure interaction model presented in this study can simulate structural behaviour of a stented valve with flexible leaflets, providing insight into the haemodynamic performance of a polymeric aortic valve. |
| DOI | 10.1007/s13239-018-0340-7 |
| Alternate Journal | Cardiovasc Eng Technol |
| PubMed ID | 29322329 |
Related Institute:
Dalio Institute of Cardiovascular Imaging (Dalio ICI)