Title | High-resolution QSM for functional and structural depiction of subthalamic nuclei in DBS presurgical mapping. |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | Dimov AV, Gupta A, Kopell BH, Wang Y |
Journal | J Neurosurg |
Volume | 131 |
Issue | 2 |
Pagination | 360-367 |
Date Published | 2018 08 10 |
ISSN | 1933-0693 |
Keywords | Adult, Aged, Brain Mapping, Deep Brain Stimulation, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Parkinson Disease, Preoperative Care, Subthalamic Nucleus |
Abstract | OBJECTIVE: Faithful depiction of the subthalamic nucleus (STN) is critical for planning deep brain stimulation (DBS) surgery in patients with Parkinson's disease (PD). Quantitative susceptibility mapping (QSM) has been shown to be superior to traditional T2-weighted spin echo imaging (T2w). The aim of the study was to describe submillimeter QSM for preoperative imaging of the STN in planning of DBS. METHODS: Seven healthy volunteers were included in this study. T2w and QSM were obtained for all healthy volunteers, and images of different resolutions were reconstructed. Image quality and visibility of STN anatomical features were analyzed by a radiologist using a 5-point scale, and contrast properties of the STN and surrounding tissue were calculated. Additionally, data from 10 retrospectively and randomly selected PD patients who underwent 3-T MRI for DBS were analyzed for STN size and susceptibility gradient measurements. RESULTS: Higher contrast-to-noise ratio (CNR) values were observed in both high-resolution and low-resolution QSM images. Inter-resolution comparison demonstrated improvement in CNR for QSM, but not for T2w images. QSM provided higher inter-quadrant contrast ratios (CR) within the STN, and depicted a gradient in the distribution of susceptibility sources not visible in T2w images. CONCLUSIONS: For 3-T MRI, submillimeter QSM provides accurate delineation of the functional and anatomical STN features for DBS targeting. |
DOI | 10.3171/2018.3.JNS172145 |
Alternate Journal | J Neurosurg |
PubMed ID | 30095333 |
Grant List | R01 CA178007 / CA / NCI NIH HHS / United States R21 EB024366 / EB / NIBIB NIH HHS / United States R01 NS090464 / NS / NINDS NIH HHS / United States R01 NS095562 / NS / NINDS NIH HHS / United States S10 OD021782 / OD / NIH HHS / United States |
Related Institute:
MRI Research Institute (MRIRI)