Brain oxygen extraction fraction mapping in patients with multiple sclerosis.

TitleBrain oxygen extraction fraction mapping in patients with multiple sclerosis.
Publication TypeJournal Article
Year of Publication2022
AuthorsCho J, Nguyen TD, Huang W, Sweeney EM, Luo X, Kovanlikaya I, Zhang S, Gillen KM, Spincemaille P, Gupta A, Gauthier SA, Wang Y
JournalJ Cereb Blood Flow Metab
Volume42
Issue2
Pagination338-348
Date Published2022 02
ISSN1559-7016
KeywordsAdult, Brain, Brain Mapping, Cerebrovascular Circulation, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Multiple Sclerosis, Oxygen, Oxygen Consumption, Retrospective Studies
Abstract

We aimed to demonstrate the feasibility of whole brain oxygen extraction fraction (OEF) mapping for measuring lesion specific and regional OEF abnormalities in multiple sclerosis (MS) patients. In 22 MS patients and 11 healthy controls (HC), OEF and neural tissue susceptibility () maps were computed from MRI multi-echo gradient echo data. In MS patients, 80 chronic active lesions with hyperintense rim on quantitative susceptibility mapping were identified, and the mean OEF and within the rim and core were compared using linear mixed-effect model analysis. The rim showed higher OEF and than the core: relative to their adjacent normal appearing white matter, OEF contrast = -6.6 ± 7.0% vs. -9.8 ± 7.8% (p < 0.001) and contrast = 33.9 ± 20.3 ppb vs. 25.7 ± 20.5 ppb (p = 0.017). Between MS and HC, OEF and were compared using a linear regression model in subject-based regions of interest. In the whole brain, compared to HC, MS had lower OEF, 30.4 ± 3.3% vs. 21.4 ± 4.4% (p < 0.001), and higher , -23.7 ± 7.0 ppb vs. -11.3 ± 7.7 ppb (p = 0.018). Our feasibility study suggests that OEF may serve as a useful quantitative marker of tissue oxygen utilization in MS.

DOI10.1177/0271678X211048031
Alternate JournalJ Cereb Blood Flow Metab
PubMed ID34558996
Grant ListK99 NS123229 / NS / NINDS NIH HHS / United States
R01 NS090464 / NS / NINDS NIH HHS / United States
R01 NS104283 / NS / NINDS NIH HHS / United States
R01 NS105144 / NS / NINDS NIH HHS / United States
S10 OD021782 / OD / NIH HHS / United States
Related Institute: 
MRI Research Institute (MRIRI)

Weill Cornell Medicine
Department of Radiology
525 East 68th Street New York, NY 10065